- Feb 2 Battle of Mortimer's Cross: in a major battle of the War of the Roses Yorkist army of Edward, Earl of March, defeats Lancaster force led by Jasper Tudor
Battle of Towton
Mar 29 Wars of the Roses: Battle of Towton - Duke Edward of York defeats the Lancastrian army, deposes King Henry VI and Queen Margaret of Anjou and proclaims himself as King Edward IV
- Jun 28 Yorkist Edward IV crowned King of England after deposing Henry VI from the House of Lancaster
- Aug 7 Ming Dynasty Chinese military general Cao Qin stages a coup against the Tianshun Emperor
- Aug 10 Alfonso ed Espina, bishop of Osma urges for an Inquisition in Spain
- Aug 15 Empire of Trebizond surrenders to forces of Sultan Mehmet II - last Byzantine Empire remnant to fall. Emperor David exiled and later murdered.
- Nov 20 Astronomer Regiomontanus returns with Cardinal Basilios Bessarion's to his house in Rome, home to one of largest libraries in Europe
Gregory I
Gregory XIII
Julius II
Julius III
Leo X
Pius V