King Henry VIII
Apr 22 Henry VIII, 2nd Tudor king of England ascends to the throne at age 17, after the death of his father, Henry VII
- Apr 27 Pope Julius II excommunicates the Republic of Venice, and endorses his allies to attack
- May 14 Battle of Agnadello, French forces under Louis XII defeat the Venetians in Northern Italy
- Jun 24 Henry VIII is crowned King of England in Westminster Abbey, London
- Jul 17 Venice recaptures nearby Italian city of Padua
- Aug 8 Emperor Krishnadeva Raya is crowned, marking the beginning of the regeneration of the Vijayanagara Empire in Southern India
- Sep 26 Storm surge causes the second Cosmas and Damian flood in East Friesland and the Netherlands destroying dykes and devastating coastal towns
- Oct 12 Holy Roman Emperor Maximilian I leaves Italy
Gregory I
Gregory XIII
Julius II
Julius III
Leo X
Pius V