- May 6 Suriname sold to Great Britain (until Feb 1816)
Addington Replaced by Pitt the Younger
May 10 British Prime Minister Henry Addington resigns, replaced by William Pitt the Younger
Lewis and Clark Set Out
May 14 Meriwether Lewis and William Clark's expedition sets out from St. Louis for the Pacific Coast, commissioned by Thomas Jefferson
Napoléon Proclaimed Emperor
May 18 Napoléon Bonaparte is proclaimed Emperor of France by the French Senate
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