- Mar 1 16th Grand National: John Tasker wins aboard race favourite Bourton at 4/1
- Mar 1 German psychologist Friedrich Eduard Beneke disappears; two years later his remains are found in a canal near Charlottenburg.
- Mar 1 SS City of Glasgow leaves Liverpool harbour with approximately 480 passengers and crew; she was never seen again
- Mar 7 Charles Miller patents 1st US sewing machine to stitch buttonholes
Perry Expedition
Mar 8 US Commodore Matthew C. Perry's second trip to Japan
- Mar 17 1st park land purchased by a US city, Worcester, Massachusetts
Republican Party Founded
Mar 20 Anti-slavery activists within the US Whig political party opposed to the Kansas-Nebraska Act form a new Republican Party; notable politicians who switched allegiance include Abraham Lincoln, Rutherford B. Hayes, Chester A. Arthur, and Benjamin Harrison
- Mar 20 Boston Public Library opens in Boston, Massachusetts as the first large free municipal library in the US [1]
- Mar 20 Republican Party formally organized in Ripon, Wisconsin
- Mar 28 Great Britain and France declare war on Russia, expanding the Crimean War
- Mar 31 Treaty of Kanagawa: Commodore Perry forces Japan to opens ports to US
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