Ferdinand II of Aragon (1452-1516)
Jan 23 King of Aragon (1479-1516), King of Naples (1504-16), dies at 63
- Mar 13 Vladislav II, King of Bohemia (1471-1516) and King of Hungary (1490-1516), dies at 60
- Mar 17 Giuliano de' Medici, ruler of Florence, dies at 37
- Apr 25 John Yonge, English diplomat (b. 1467)
- Jul 30 Johan V Nassau, earl of Nassau-Vianden/Dietz, dies
- Aug 9 Hieronymus Bosch, Dutch painter (Garden of Earthly Delights), dies at 66
- Aug 21 John III of Egmont [Jan van Egmond], Viceroy of Holland, Viceroy of Holland, dies at 78
- Dec 13 Johannes Trithemius, German cryptographer, dies at 54
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide