- Jan 1 Hermann Vischer, the Younger, German bronze merchant, dies at 31
- Mar 7 Maria of Aragon, queen of Portugal (1500-17), dies at 34
- Mar 26 Heinrich Isaac, Flemish composer, dies at about 67 [birth date uncertain, c. 1450]
- Apr 13 Tuman bay II, last Mamelukken sultan of Egypt, dies at 40
- Sep 24 Frederik IV, of Baden, bishop of Utrecht, dies
- Oct 2 John Murmelius, humanist/theory/school book writer, dies at about 37
- Oct 31 Fra Bartolommeo, Italian artist, dies at 45
- Nov 8 Francisco Jimenez de Cisneros, cardinal/Chancellor of Castilia, dies
Assassination
Car Crash
Hanging
Killed in Action
Plane Crash
Poisoning