- Jan 17 Santino Garsi da Parma, Italian lutenist and composer, dies at 61
- Feb 29 John Whitgift, Archbishop of Canterbury (1583-1604), dies at about 74
- Mar 4 Fausto Paolo Sozzini, Italian theologian and founder of Socinianism, dies at 64
- Mar 13 Arnaud d'Ossat, French diplomat and writer, dies at 66
- Apr 4 Thomas Churchyard, poet/pamphleteer, dies
- May 4 Claudio Merulo, Italian organist and composer, dies at 71
- Jun 24 Edward de Vere, 17th Earl of Oxford, Lord Great Chamberlain of England, dies at 54
- Aug 3 Bernardino de Mendoza, Spanish military commander
- Aug 8 Horio Tadauji, Japanese warlord (b. 1578)
- Aug 31 Giovanale Ancina, Italian priest and composer, dies of purported poisoning at 58
- Sep 10 William Morgan, Welsh Bible translator (b. 1545)
- Sep 12 Louis Gunther, Count of Nassau, dies in battle at about 29
- Sep 17 Lucas Osiander, German composer, dies at 69
- Oct 8 Janus Dousa [Johan van de Does], Dutch politician and poet, dies at 58
- Oct 18 Igram van Achelen, Dutch statesman (b. 1528)
- Oct 25 Claude de la Tremoille, French duke of Thouars/huguenot, dies
Assassination
Drug Overdose
Gunshot Wound
Murder
Plane Crash
Suicide