- Feb 19 Orazio Tiberio Vecchi, Italian composer, dies at 54
- Mar 5 Clement VIII [Ippolito Aldofireini], Italian Pope (1592-1605), dies at 69
- Mar 17 Pieter Bast [Bastius], Dutch engraver/cartographer, dies at about 34
- Apr 5 Adam Loftus, English Protestant archbishop in Ireland (c.1513)
- Apr 6 John Stow, English historian (Survey of London), dies
- Apr 13 Boris Godunov, Tsar of Russia (1598-1605) and chief adviser to Tsar Fyodor I, dies after a lengthy illness and a stroke at 52
- Apr 25 Naresuan, King of Siam (b. 1555)
- Apr 27 Leo XI [Alessandro Ottaviano de' Medici], Italian Pope in 1605 who had the shortest reign as pope in history, dies at 69
- May 4 Ulisse Aldrovandi, Italian biologist and naturalist, dies at 82
- Sep 14 Jan Tarnowski, Archbishop of Kraków (b. 1550)
- Sep 23 Pontus de Tyard, French poet and priest, who a member of the Renaissance poets "La Pléiade", dies at about 84
- Sep 24 Manuel Mendes, Portuguese composer and teacher of the Renaissance, dies at about 58
- Oct 13 Theodore Beza, French Reformed Protestant theologian, dies at 86
Robert Catesby (c. 1572-1605)
Nov 8 English conspirator (Gunpowder Plot), killed at about 32
- Dec 28 John David, English navigator for Queen Elizabeth I (discovered Falkland Islands), killed by pirates in the East Indies at 54 or 55
Assassination
Car Crash
Hanging
Killed in Action
Plane Crash
Poisoning