- Jan 9 John Haynes, 5th Governor of the Massachusetts Bay Colony, dies at 58
- Feb 16 Johannes Schultz, German composer, dies at 70
- Feb 19 Luigi Rossi, Italian early baroque composer, dies at about 55
- Feb 21 Adriaen Pauw, master of Heemstede and Dutch Grand Pensionary, dies at 71
- Mar 23 Johan van Galen, Dutch admiral (commanded Dutch fleet during Battle of Leghorn), dies of wounds from the Battle of Leghorn at about 48
- May 10 John Bicker, ship builder/merchant/regent, dies at 61
- May 18 Carel Reyniersz, Governor General of the Dutch East Indies, dies at 48
- May 19 Carel Reyniersz, Dutch colonial administrator and Governor-General of the Dutch East Indies (1650-53), dies at 48
- May 26 Robert Filmer, English writer (b. 1588)
- Jul 10 Gabriel Naudé, French librarian and scholar (b. 1600)
- Jul 31 Thomas Dudley, British colonial governor of Massachusetts, dies at 76
Maarten Tromp (1598-1653)
Aug 10 Dutch admiral (Eighty Years' War, First Anglo-Dutch War), killed in the Battle of Scheveningen by a sharpshooter at 55
- Aug 29 Gillesz de Hondecoeter, painter/Hostage rights, buried at about 49
- Sep 3 Claudius Salmasius [Claude Saumaise], French linguist, dies at 65
- Sep 20 Humphrey Chetham, English cloth merchant (his will leaves money to establish Chetham Library - oldest English language public library in the world), dies at 72 [1]
- Oct 3 Mark Zuesius Boxhorn, Dutch historian, dies at 41
- Oct 7 Fausto Poli, Italian Catholic priest (b. 1581)
- Nov 26 Maximilian Teellinck, vicar, dies at about 51
Assassination
Car Crash
Hanging
Killed in Action
Plane Crash
Poisoning