- Jan 1 Gregory Blaxland, Australian explorer, dies of suicide at 74
- Jan 3 Theodor Uhlig, composer, dies at 30
- Jan 9 Juan Nicasio Gallego, Spanish poet and interpreter (El dos de Mayo), dies at 75
- Jan 13 Theophilos Kairis, Greek priest, humanist and revolutionary (b. 1783)
- Mar 4 Christian Leopold von Buch, German geologist and paleontologist, dies at 78
- Mar 5 August Kestner, German art collector and diplomat, dies at 75
- Mar 8 Edward John Dent, British clockmaker to Queen Victoria and commissioned to make Big Ben, London (completed after his death by his son Frederick Dent), dies at 62
- Apr 8 Jan Willem Pieneman, Dutch historical painter (Battle at Waterloo), dies at 73
- Apr 11 Louis-Emmanuel Jadin, French pianist, music director, and composer, dies at 84
- Apr 13 James Iredell, Jr., American politician, dies at 64
- Apr 13 Leopold Gmelin, German chemist (Gmelin's test), dies at 64
- Apr 15 Johann Leopold Fuchs, German composer, dies at 67
- Apr 18 William R. King, American politician (Vice President 1853), dies at 67 one month after his inauguration
- Apr 23 Auguste Laurent, French chemist who laid the foundations of organic chemistry, dies of tuberculosis at 45
William Beaumont (1785-1853)
Apr 25 American surgeon and father of gastric physiology, dies at 67
- Apr 28 Ludwig Tieck, German writer, dies at 79
- May 8 Jan Roothaan, 1st Dutch general of the Jesuits (1829-53), dies at 67
- May 9 Johann Philipp Samuel Schmidt, German composer, dies at 73
- Jun 12 Johannes Cornelis de Jonge, Dutch historian and archivist, dies at 60
- Jun 18 Branko Radicevic, Serbian poet (1st Serbian Uprising), dies of tuberculosis at 29
- Jul 23 Andries Pretorius, Boer leader (Pretoria named after him), dies at 54
- Jul 25 Joaquin Murieta, Mexican-born Californian outlaw (inspired fictional character Zorro), killed by Californian Rangers at 23 or 24
- Aug 6 Josif Josifovich Genishta, Russian pianist, composer, and conductor, dies at 57
- Aug 15 Giovanni Battista Polledro, Italian composer, dies at 72
- Aug 18 Peter Lichtenthal, Austrian composer, musicologist, and physician, dies at 73
- Aug 23 Alexander Calder, first mayor of Beaumont, Texas (b. 1806)
Charles Napier (1782-1853)
Aug 29 British soldier and Major General of the Bombay Army who conquered Sindh and became its Governor (1843-47), dies at 71
- Sep 4 Jonathan Blewitt, English organist and composer, dies at 71
- Sep 8 Frédéric Ozanam, French scholar and founder of the Society of Saint Vincent de Paul, dies at 40
- Oct 2 François Arago, French astronomer, physicist (chromosome) and politician, dies at 67
- Oct 3 George Onslow, British-French composer, chiefly of chamber music, dies at 69
- Oct 29 Pierre-Joseph-Guillaume Zimmermann, French pianist, music teacher, and composer, dies at 68
- Oct 29 William Richard Bexfield, English composer, dies at 29
- Oct 30 Pietro Raimondi, Italian composer (Triple Oratorio:, Putifar-Giuseppe-Giacobbe), dies at 66
- Nov 4 Alexander Stadtfeld, German composer, dies at 27
Maria II (1819-1853)
Nov 15 Daughter of Emperor Pedro I of Brazil, dies at 34
Assassination
Car Crash
Hanging
Killed in Action
Plane Crash
Poisoning