Battle of Ravenna
Apr 11 Battle of Ravenna: French forces under Gaston de Foix defeat the Holy League in a major battle of the Italian Wars
- Aug 10 Battle of Saint-Mathieu (also called the Battle of Brest): an English fleet of 25 ships commanded by Sir Edward Howard and a Franco-Breton fleet of 22 ships commanded by René de Clermont.
Luther's Doctorate
Oct 19 Martin Luther becomes a doctor of theology (Doctor in Biblia)
- Oct 21 Martin Luther joins the theological faculty of the University of Wittenberg.
Ceiling of the Sistine Chapel
Nov 1 Michelangelo's paintings on ceiling of the Sistine Chapel in the Vatican first exhibited
Niccolo Machiavelli
Nov 7 Medici's discharge Niccolo Machiavelli from Florence
- Dec 27 Spanish Crown issues the Laws of Burgos, governing the conduct of settlers with regards to native Indians in the New World