Council of Trent
May 1 Council of Trent resumes, overseen by Pope Julius III
- May 12 San Marcos University in Lima, Peru, opens (oldest continuously operating university in the Americas)
- Jun 8 Pope Julius III excommunicates the Duke of Parma, Ottavio Farnese
- Jul 19 Treaty of Karlsburg: arch duke Ferdinand of Austria recognized as King of Hungary/Transsylvania
- Aug 14 Ottoman fleet under Dragut captures Tripoli from The Knights of Malta after a six-day bombardment
- Oct 16 English Edward Seymour Duke of Somerset and former Lord Protector, re-arrested for treason - executed three months later
- Dec 19 Dutch west coast hit by hurricane