- Jan 7 Carl Gustaf Tessin, Swedish politician, dies at 74
- Jan 20 Charles Yorke, Lord Chancellor of Great Britain (b. 1722)
- Feb 22 Christopher Snider, 11, Boston, becomes 1st martyr of US Revolution
- Feb 26 François Hanot, French composer and violinist, dies at 72
- Feb 26 Giuseppe Tartini, Venetian Baroque composer and violinist (Trillo del Diavolo), dies at 77
Crispus Attucks (c. 1723-1770)
Mar 5 possible slave, is 1st of 5 killed during Boston Massacre at beginning of the American Revolution
- Mar 27 Giovanni Battista Tiepolo, Italian Venetian Rococo painter (Banquet of Cleopatra), dies at 73
- Apr 19 Esprit Antoine Blanchard, French composer, dies at 74
- Apr 25 Jean-Antoine Nollet, French clergyman and physicist (discovery of osmosis), dies at 69
- Apr 28 Marie-Anne de Cupis de Camargo, French dancer, dies at 60
- May 4 Christian Gottfried Krause, German composer, dies at 51
- May 10 Charles Avison, English composer, dies at 61
- May 27 Sophie Magdalene of Brandenburg-Kulmbach, Queen consort of Denmark and Norway (1730-46), dies at 69
- May 30 François Boucher, French painter (b. 1703)
- Jun 23 Mark Akenside, English poet and physician, dies at 48
- Jul 14 David 't Kindt, Flemish architect (Mammelokker, Ghent), dies at 71
- Jul 16 Francis Cotes, English painter (b. 1726)
- Jul 26 Michael Scheuenstühl, German composer, dies at 65
- Jul 27 Robert Dinwiddie, British colonial governor of Virginia (b. 1693)
- Aug 24 Thomas Chatterton, English poet (Revenge), dies at 17
- Aug 26 Domingos dos Reis Quita, Portuguese playwright and poet, dies at 42
- Sep 9 Bernard Siegfried Albinus [Weiss], German surgeon and anatomist (1st to link vascular system with the fetus), dies at 73
- Sep 9 Georg Dionysius Ehret, German-English botanist and cartoonist, dies at 62
George Whitefield (1714-1770)
Sep 30 English-born Methodist leader and preacher, dies in Newburyport, Massachusetts, at age 55
- Sep 30 Thomas Robinson, 1st Baron Grantham, English politician and diplomat
- Oct 1 Louis-Gabriel Guillemain, French composer and violinist, dies at 64
- Oct 18 John Manners, Marquess of Granby, British soldier (b. 1721)
- Nov 1 Alexander Cruden "Alexander the Corrector", Scottish biblical scholar and eccentric, compiler of a concordance to King James Bible, dies at 71
- Nov 9 John Campbell, 4th Duke of Argyll, Scottish politician
George Grenville (1712-1770)
Nov 13 British Prime Minister (1763-65) who introduced the Stamp Act (1st international tax to the colonies in America), dies at 58
- Nov 17 Gian Francesco de Majo, Italian composer, dies at 38
- Nov 24 Charles-Jean-François Hénault, French historian (b. 1685)
- Dec 5 James Stirling, Scottish mathematician (Formula of Stirling), dies at 78
- Dec 9 Gottlieb Theophil Muffat, German composer, dies at 80
- Dec 10 Theophil "Gottlieb" Muffat, German court organist and composer, dies at 80