Francis I Ascends Throne
Jan 1 Francis, Duke of Angouleme succeeds King Louis XII as Francis I of France
- Jan 1 Jews are expelled from Laibach in Austria
Recapture of Hormuz
Apr 1 Portuguese fleet under Afonso de Albuquerque captures the Persian fortress of Hormuz, renaming it the Fort of Our Lady of the Conception
- May 19 George van Saksen-Meissen sells Friesland for 100,000 gold guilders to arch duke Charles
- Jul 22 First Congress of Vienna settles issues between Poland and Holy Roman Empire - rise of the Habsburgs influence
- Aug 25 Conquistador Diego Velázquez de Cuéllar founds Havana in modern day Cuba, on the southern coast of the island. Moved to its current location in 1519.
- Sep 13 First day of two-day Battle of Marignano: Francis I's French army defeats Swiss army force near Milan
- Sep 14 Battle at Marignano ends after two days in a French and Venetian victory over a Swiss army
- Nov 15 Thomas Wolsey is invested as an English Cardinal
- Dec 24 Thomas Wolsey appointed Lord Chancellor of England
Gregory I
Gregory XIII
Julius II
Julius III
Leo X
Pius V