Treaty of Westminster
Apr 30 Henry VIII of England and Francis I of France sign the Treaty of Westminster, pledging to combine their forces against Holy Roman Emperor Charles V in attempt to win War of the League of Cognac
Sack of Rome
May 6 Spanish and German Imperial troops sack Rome, ending the Renaissance. Charles III, Duke of Bourbon is killed in the assault removing any restraint for the victorious soldiers.
Clement VII Surrenders
Jun 7 Pope Clement VII surrenders to Emperor Charles V's armies
Paracelsus' Protest
Jun 24 Paracelsus publicly burns standard medical textbooks at the University of Basel, as a protest against the current teaching and practice of medicine
- Aug 3 First known letter sent from North America by John Rut while at St. John's, Newfoundland
- Nov 3 Ferdinand of Austria and Bohemia chosen as king of Hungary
- Nov 15 Treaty of Schoonhoven: Henry of the Palatinate, Bishop of Utrecht, cedes lands to the Habsburgs in return for security help against resistant citizens
Pope Clement VII Flees
Dec 6 Pope Clement VII escapes imprisonment in the Castel Sant'Angelo in Rome, fleeing to Orvieto disguised as a peddler
- Dec 12 Composer Adrian Willaert moves from Milan to Venice
Gregory I
Gregory XIII
Julius II
Julius III
Leo X
Pius V