Schmalkaldic League
Apr 9 Danish king Christian III enters Schmalkaldische Union
John Calvin Expelled
May 26 Geneva expels John Calvin and his followers from the city. Calvin lives in exile in Strasbourg for the next three years.
- Jun 10 Catholic German monarchy signs League of Neuremberg, in response to the formation of the Protestant Schmalkaldic League
- Jul 25 The City of Guayaquil is founded by the Spanish Conquistador Francisco de Orellana and given the name Muy Noble y Muy Leal Ciudad de Santiago de Guayaquil
- Jul 30 St Augustine's Abbey, one of the most important monasteries in England, is dissolved - its Abbot John Essex and 30 monks leave voluntarily, before it is ransacked [1]
- Aug 6 Bogotá, Colombia, is founded by Gonzalo Jiménez de Quesada
- Sep 21 Shrine of Saint Swithun in Winchester smashed up in the middle of the night as part of the English Reformation
- Sep 28 Battle at Preveza: Ottoman fleet under Barbarossa beats Papal alliance off Northwestern Greece
- Oct 28 The first university in the New World, the Universidad Santo Tomás de Aquino, is established on Hispaniola
Henry VIII Excommunicated
Dec 17 Pope Paul II excommunicates King Henry VIII of England
Gregory I
Gregory XIII
Julius II
Julius III
Leo X
Pius V