- Feb 15 Emperor Charles receives Cardinal Pole in Toledo
- Feb 19 Jews of Tyrnau Hungary (then Trnava Czech), expelled
- Apr 19 Charles, protestant German monarch, signs Treaty of Frankrfurt
- Apr 27 Re-founding of the city of Bogotá, New Granada (now Colombia), by Nikolaus Federmann and Sebastián de Belalcázar.
De Soto's Expedition Lands in Florida
May 30 Spanish explorer Hernando de Soto's expedition of 10 ships and 700 men lands in Florida
Hernando De Soto Lands in Florida
Jun 3 Spanish conquistador Hernando De Soto claims Florida for Spain
Gregory I
Gregory XIII
Julius II
Julius III
Leo X
Pius V