- Feb 9 The first recorded race meet in England (Roodee Fields, Chester)
Seven Cities of Gold
Feb 23 Francisco Vázquez de Coronado's expedition sets off from Mexico in search of the Seven Cities of Gold (Cibola)
De Soto Crosses Appalachians
Jun 3 Spanish conquistador Hernando de Soto crosses the Appalachian Mountains, 1st European to do so
Cromwell Arrested
Jun 10 Former chief minister to King Henry VIII, Thomas Cromwell is arrested in Westminster for treason and heresy
Henry VIII Expels Anne of Cleves
Jun 24 English King Henry VIII commands his 4th wife, Anne of Cleves, to leave the court
- Jun 29 UK parliament passes The Act of Attainder over former Chancellor of the Exchequer of England Thomas Cromwell, indicting him as a heretic
- Jul 23 Turkey recognizes John Sigismund Zápolya as vassal king of Hungary
- Aug 15 Arequipa is founded in Peru
- Aug 25 Explorer Hernando de Alarcon travels up Colorado River
- Aug 29 Emperor Karel deprives city Gent of its definitive rights and privileges
- Sep 27 Pope Paul III officially recognizes the Society of Jesus (Jesuit) co-founded by Ignatius of Loyola as a religious order of the Catholic church
- Oct 2 Venice and Turkey signs peace
- Oct 11 Emperor Karel names his son Philip, Duke of Milan
Gregory I
Gregory XIII
Julius II
Julius III
Leo X
Pius V